Risk Factors for Necrotizing Entercolitis Totalis

Risk Factors for Necrotizing Entercolitis Totalis
Principal Investigator	Bonnie Lang Silverman, PhD
Co-investigators	Marion C. W. Hency, MD, MPH Karen A. Diefenbach, MD R. Lawrence Moss, MD

Project Goal

to determine whether early feeding, and rapid advancement of feedings increases the risk for development of NEC Totalis in premature infants, and
to determine whether there are clinical changes which predict the onset of NEC Totalis.

Study Design

A case control study nested in the cohort of premature infants admitted to the Yale Newborn Special Care Unit over a 10 year period.

Risk Factors of Interest :

gender
race
birth weight
gestational age
birth weight percentile
clinical status 24 – 48 hours before the onset
feeding patterns
presence of sepsis
need for mechanical ventilation
perinatal risk factors that may increase risk for NEC: Apgar score, route of delivery, and maternal factors.

Outcome :Development of NEC Totalis.

Data Collection

Abstraction of data from medical record onto paper forms, data entry using Stata V 9.0

Data Management

Data management and analysis: Stata v 9.0

Funding

none at present

Timeline

Start date: Jan, 2006

End date: Dec, 2006

Status: Jan 2006

Data collection phase